Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 77,500 |
5 mg | 在庫あり | ¥ 164,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 388,000 |
50 mg | 在庫あり | ¥ 521,000 |
100 mg | 在庫あり | ¥ 682,000 |
説明 | MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
ターゲット&IC50 | Cell proliferation:11 nM(HCT116 MTAP-del cells), Cell proliferation:861 nM(HCT116 MTAP-WT cells), SDMA:3 nM(HCT116 MTAP-del cells), SDMA:544 nM(HCT116 MTAP-WT cells) |
In vitro | MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM). |
In vivo | In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow[1]. |
分子量 | 424.43 |
分子式 | C24H17FN6O |
CAS No. | 2629314-68-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/ml(82.46 mM)
You can also refer to dose conversion for different animals. 詳細
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MRTX9768 2629314-68-5 Chromatin/Epigenetic Histone Methyltransferase SDMA toxicity glioblastoma orally low Inhibitor hematological MTAP CDKN2A inhibit anticancer PRMT5-MTA MRTX-9768 MRTX 9768 inhibitor