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T2561 |
Macitentan
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ACT-064992 |
Apoptosis
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Endothelin Receptor
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Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
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T11934 |
Macitentan-d4
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Macitentan D4,ACT-064992 D4 |
Endothelin Receptor
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Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer... |
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T11935 |
Macitentan (n-butyl analogue)
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Others
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Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros... |
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TMIH-0383 |
N-Despropyl Macitentan-d4
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N-Despropyl Macitentan-d4 is a deuterated compound of N-Despropyl Macitentan. N-Despropyl Macitentan has a CAS number of 1103522-45-7. Aprocitentan is ETA and ETB antagonist . |
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T7817 |
Aprocitentan
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ACT-132577 |
Endothelin Receptor
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Aprocitentan (ACT-132577) is ETA and ETB antagonist . |
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T35623 |
ACT-373898
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ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1
1.Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan... |
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T10351 |
Aprocitentan D4
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ACT-132577 D4 |
Others
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Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2... |
