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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8879 | MR837 | ZINC30303842,NSD2-PWWP1 antagonist 3f | Others , Histone Methyltransferase |
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist. | |||
T62705 | NSD2-IN-1 | ||
NSD2-IN-1 (compound 38) serves as a potent and highly selective inhibitor of NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1), demonstrating an IC50 value of 0.11 μM. By binding to NSD2-PWWP1, NSD2-IN-1 impacts t... | |||
T79617 | NSD2-IN-4 | Histone Methyltransferase | |
NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1]. | |||
T9006 | LEM-14 | Others | |
LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma. | |||
T72979 | LEM-14-1189 | Histone Methyltransferase | |
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 μM, 111 μM, and 60 μM, respectively. LEM-14-118... | |||
T9584 | UNC6934 | Others , Histone Methyltransferase | |
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. | |||
T12263L | NSC305787 hydrochloride | (Rac)-NSC305787 hydrochloride | Others |
T79616 | UNC7096 | Histone Methyltransferase | |
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1]. | |||
T77967 | MS159 | PROTACs | |
MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's... | |||
T12083 | MMSET-IN-1 | Others | |
MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) . | |||
T83867 | UNC8153 TFA | ||
UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentrati... | |||
T10538 | BI-9321 | Others | |
BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T10538L | BI-9321 trihydrochloride | Others | |
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T36802 | Bisubstrate Inhibitor 78 | ||
Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinam... | |||
T36978 | AS-99 TFA | ||
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and different... |