| T36256 |
LC-2
|
2502156-03-6
|
98%
|
|
|
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PR...
|
| T11980 |
MD-224
|
2136247-12-4
|
100%
|
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
|
| T75129 |
Luxdegalutamide
|
2750830-09-0
|
100%
|
|
|
Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wil...
|
| T39954 |
AU-15330
|
2380274-50-8
|
100%
|
|
|
AU-15330 is a protein hydrolysis-targeted chimeric (PROTAC) degrader of the SWI/SNF ATPase subunits SMARCA2 and SMARCA4.AU-15330 potently inhibits tumor growth i...
|
| T74186 |
PROTAC-O4I2
|
2785323-62-6
|
96.31%
|
|
|
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 indu...
|
| T16157 |
MT-802
|
2231744-29-7
|
97%
|
|
|
MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
|
| T20967 |
Methyltetrazine-Amine
|
1345955-28-3
|
97.59%
|
|
|
Methyltetrazine-Amine is a methyl-substituted tetrazine amine used in the synthesis of PROTAC molecules.
|
| T5442 |
A1874
|
2064292-12-0
|
98%
|
|
|
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
|
| T74643 |
RSS0680
|
2769753-48-0
|
98.02%
|
|
|
RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
|
| T17350 |
ACBI1
|
2375564-55-7
|
98.15%
|
|
|
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
|
| T67834 |
C004019
|
2417159-57-8
|
99.37%
|
|
|
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selecti...
|
| T9384 |
Pomalidomide-PEG3-OH
|
2140807-36-7
|
99.65%
|
|
|
Pomalidomide-PEG3-OH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
|
| T17017 |
TCO-PEG4-NHS ester
|
1613439-69-2
|
99.75%
|
|
|
TCO-PEG4-NHS ester is a PROTAC linker bridge belonging to the PEG class.TCO-PEG4-NHS ester can be used to synthesize a wide range of PROTAC molecules.TCO-PEG4-NH...
|
| T31221 |
DBRD9
|
2170679-45-3
|
99.81%
|
|
|
dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquiti...
|
| T9383 |
Pomalidomide-PEG2-OH
|
2143097-10-1
|
99.98%
|
|
|
Pomalidomide-PEG2-OH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
|
| T75026 |
PROTAC TYK2 degradation agent1
|
2921556-14-9
|
98%
|
|
|
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmun...
|
| T74851 |
PROTAC CDK9 degrader-5
|
2935587-89-4
|
98%
|
|
|
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isofor...
|
| T74635 |
MS9449
|
2772612-96-9
|
98%
|
|
|
MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degrad...
|
| T74557 |
α1A-AR Degrader 9c
|
2863635-02-1
|
98%
|
|
|
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the ...
|
| T74259 |
PF15
|
2892631-70-6
|
98%
|
|
|
PF15, a selective FLT3-ITD degrader, serves as a PROTAC (proteolysis targeting chimera) tethering ligands for FLT3 kinase and CRBN. It exhibits a degradation con...
|
