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Search Results for " PRMT5-MTA "

ターゲット

Histone Methyltransferase

4

阻害剤

カタログ番号	製品名	別名	ターゲット
T40254	MRTX-1719		Histone Methyltransferase
	MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.		Histone Methyltransferase
T9575	MRTX9768		Histone Methyltransferase
	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.		Histone Methyltransferase
T79873	TNG-462		Histone Methyltransferase
	TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1].		Histone Methyltransferase
T36630	MRTX9768 hydrochloride
	MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT...

Compounds

Target: Histone Methyltransferase

Target: Histone Methyltransferase

Target: Histone Methyltransferase

MRTX9768 hydrochloride

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