megakaryocytes | TargetMol

カタログ番号	製品名	別名	ターゲット
T13769	TA-316	Megakaryocytes/platelets inducing agent	Others
	Megakaryocytes/platelets inducing agent being useful in treating diseases involving thrombopenia. Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cel...		Others
T7417	Avatrombopag	YM477,AKR-501,E5501	Thrombin , Thrombopoietin Receptor
	Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.		Thrombin , Thrombopoietin Receptor
T4570	Pipobroman	Vercyte,A-8103,Amedel	Others , DNA Alkylator/Crosslinker
	Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...		Others , DNA Alkylator/Crosslinker
TP2342	Krds peptide	Lys-arg-asp-ser
	Krds peptide is a synthetic tetrapeptide derived from lactotransferrin (residues 39 to 42) that suppresses binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-Stimulated platelets and megakaryocytes.
T68560	Totrombopag choline
	Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and po...
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis througho...
T40654	Avatrombopag hydrochloride	AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet prod...

Compounds

TA-316

T13769

Synonym: Megakaryocytes/platelets inducing agent

Target: Others

Avatrombopag

T7417

Synonym: YM477,AKR-501,E5501

Target: Thrombin, Thrombopoietin Receptor

Pipobroman

T4570

Synonym: Vercyte,A-8103,Amedel

Target: Others, DNA Alkylator/Crosslinker

Krds peptide

TP2342

Synonym: Lys-arg-asp-ser

Avatrombopag hydrochloride

T40654

Synonym: AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00235	TPO Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of me...
TMPK-00620	TLT-1/TREML1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Triggering receptor expressed on myeloid cells (TREM)-like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. Triggering receptor expressed on myeloid cells (TREM...
TMPK-00590	IL-3 Protein, Human, Recombinant (E. coli)	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00049	IL-3 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00655	IL-3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00033	IL-3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00031	IL-3 Protein, Human, Recombinant (His & Avi)	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00032	IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPJ-00193	TREML1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-...
TMPJ-00978	PIP4K2A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain...
TMPJ-00012	CXCL4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with hi...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPY-01840	TLT-1/TREML1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusive...