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DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates or can crosslink DNA. Alkylation is a chemical reaction that entails the transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion, or a carbene (or their equivalents). Alkylating agents are reagents for effecting alkylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with a class of drugs called alkylating antineoplastic agents.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T1507 Streptozocin 18883-66-4 98%
Streptozocin (NSC-85998) is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimen...
T8380 Bendamustine 16506-27-7 98%
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T1488 Procarbazine hydrochloride 366-70-1 98%
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the e...
T36528 Illudin M 1146-04-9 98%
Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illud...
T6798 Tretazicar 21919-05-1 98%
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
T1241 Altretamine 645-05-6 98%
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
T4558 Trioxsalen 3902-71-4 98%
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
T17159 Treosulfan 299-75-2 98%
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T0923 Busulfan 55-98-1 98%
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
T3091 Carmustine 154-93-8 98%
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T0707L Cyclophosphamide 50-18-0 98%
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T17212 VAL-083 23261-20-3
VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T4169 N-Nitroso-N-methylurea 684-93-5
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
T4459 PK11000 38275-34-2 100%
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T4570 Pipobroman 54-91-1 93.01%
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV)...
T4350 Palifosfamide 31645-39-3 97%
Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The...
T1798 RITA 213261-59-7 97.76%
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt t...
T1055 Ifosfamide 3778-73-2 98%
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the...
T7221 Satraplatin 129580-63-8 98%
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical acti...
T1250 Thio-TEPA 52-24-4 98%
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
Streptozocin
T1507
Streptozocin (NSC-85998) is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimen...
Bendamustine
T8380
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
Procarbazine hydrochloride
T1488
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the e...
Illudin M
T36528
Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illud...
Tretazicar
T6798
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
Altretamine
T1241
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
Trioxsalen
T4558
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
Treosulfan
T17159
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
Busulfan
T0923
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
Carmustine
T3091
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Cyclophosphamide
T0707L
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
VAL-083
T17212
VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
N-Nitroso-N-methylurea
T4169
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
PK11000
T4459
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
Pipobroman
T4570
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV)...
Palifosfamide
T4350
Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The...
RITA
T1798
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt t...
Ifosfamide
T1055
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the...
Satraplatin
T7221
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical acti...
Thio-TEPA
T1250
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
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