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ATP Citrate Lyase

ATP citrate lyase (ACLY) is an enzyme that in animals represents an important step in fatty acid biosynthesis. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursors of thousands of specialized metabolites, including waxes, sterols, and polyketides.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T11590 (-)-Hydroxycitric acid 27750-10-3
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP...
T2337 BMS-303141 943962-47-8
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T5544 2-Furoic acid 88-14-2 100%
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 95%
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T7424 NDI-091143 2375840-87-0 98.61%
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
T22967 MEDICA16 87272-20-6 99.13%
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
T16861 SB 204990 154566-12-8 99.6%
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T3625 Bempedoic acid 738606-46-7 99.84%
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects as...
T12045 (-)-Hydroxycitric acid lactone 27750-13-6 99.91%
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which cata...
T79936 Forrestiacids K 2920898-65-1 98%
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
T79935 Forrestiacids J 2920898-66-2 98%
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].
(-)-Hydroxycitric acid
T11590
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP...
BMS-303141
T2337
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
2-Furoic acid
T5544
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
Hydroxycitric acid tripotassium hydrate
T11589
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
NDI-091143
T7424
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
MEDICA16
T22967
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
SB 204990
T16861
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
Bempedoic acid
T3625
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects as...
(-)-Hydroxycitric acid lactone
T12045
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which cata...
Forrestiacids K
T79936
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
Forrestiacids J
T79935
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].