Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 37,500 | |||
25 mg | 在庫あり | ¥ 74,500 | |||
50 mg | 在庫あり | ¥ 136,000 | |||
100 mg | 在庫あり | ¥ 195,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor. |
In vitro | SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1]. |
In vivo | When administered orally to rats, SB 204990 achieves systemic circulation and induces a dose-related reduction in plasma cholesterol (up to 46%) and triglyceride levels (up to 80%) upon inclusion in their diet at 0.05-0.25% (w/w) for one week. Similarly, a daily dose of 25 mg/kg of SB 204990 in dogs decreases plasma cholesterol (up to 23%) and triglyceride levels (up to 38%), with a preferential reduction in low-density lipoprotein compared to high-density lipoprotein cholesterol levels [2]. |
分子量 | 389.27 |
分子式 | C18H22Cl2O5 |
CAS No. | 154566-12-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (256.89 mM)
H2O: 10 mg/mL (25.69 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SB 204990 154566-12-8 Metabolism ATP Citrate Lyase Inhibitor inhibit ACLY SB204990 SB-204990 inhibitor