ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T8685 | SP-146 | T8685 | 98% |
|
| SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM). | ||||
| T6057 | URMC-099 | 1229582-33-5 | 98% |
|
| URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)... | ||||
| T34787 | TAS-119 | 1453099-83-6 | 98% |
|
| TAS-119 is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 ha... | ||||
| T16359 | NU6140 | 444723-13-1 | 98% |
|
| NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A ... | ||||
| T6028 | PF 477736 | 952021-60-2 | 98% |
|
| PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | ||||
| T6380 | AMG 900 | 945595-80-2 | 98% |
|
| AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ... | ||||
| T6068 | MK-5108 | 1010085-13-8 | 98% |
|
| MK-5108 is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM. | ||||
| T4428 | CCT241736 | 1402709-93-6 | 98% |
|
| CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, ... | ||||
| T35570 | Chiauranib | 1256349-48-0 | 98% |
|
| Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k... | ||||
| T5S0802 | Palmatine | 3486-67-7 | 98% |
|
| 1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has bee... | ||||
| T6458 | CYC-116 | 693228-63-6 | 98% |
|
| CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a... | ||||
| T6785 | BI-847325 | 1207293-36-4 | 98% |
|
| BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. | ||||
| T10215 | AAPK-25 | 2247919-28-2 | 98% |
|
| AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by... | ||||
| T2358 | ENMD-2076 | 934353-76-1 | 98% |
|
| ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα. | ||||
| T5524 | Aurora kinase inhibitor-3 | 879127-16-9 | 98% |
|
| Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and E... | ||||
| TQ0059 | Ilorasertib | 1227939-82-3 | 98% |
|
| Ilorasertib (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppress... | ||||
| T6532 | Hesperadin | 422513-13-1 | 98% |
|
| Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK... | ||||
| T6435 | CCT129202 | 942947-93-5 | 98% |
|
| CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less p... | ||||
| T21981 | Phthalazinone pyrazole | 880487-62-7 | 98% |
|
| Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and disp... | ||||
| T11961 | MBM-55S | 2083624-07-9 | 98% |
|
| MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce... | ||||
