ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T1524 | Nilotinib | 641571-10-0 | 98% |
|
| Nilotinib is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. | ||||
| T5177 | Asciminib | 1492952-76-7 | 98% |
|
| Asciminib (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM). | ||||
| T4618 | BGG463 | 890129-26-7 | 98% |
|
| BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively. | ||||
| T6057 | URMC-099 | 1229582-33-5 | 98% |
|
| URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)... | ||||
| T8488 | GMB-475 | 2490599-18-1 | 98% |
|
| GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the ... | ||||
| T6230 | Imatinib | 152459-95-5 | 98% |
|
| matinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit (IC50: 600/100/100 nM). | ||||
| T28374 | PF-06651481-00 | 1391063-17-4 | 98% |
|
| PF-06651481-00 is a Bosutinib analog and a Bcr-Abl inhibitor. | ||||
| T16545 | Pivanex | 122110-53-6 | 98% |
|
| Pivanex is a derivative of Butyric acid and is an orally active HDAC inhibitor. Pivanex has antimetastic and antiangiogenic properties. Pivanex down-regulates bc... | ||||
| T22378 | Nilotinib hydrochloride | 923288-95-3 | 98% |
|
| Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cog... | ||||
| T1621 | Imatinib Mesylate | 220127-57-1 | 98% |
|
| Imatinib mesylate is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively... | ||||
| T4320 | Flumatinib | 895519-90-1 | 98% |
|
| Flumatinib is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity. | ||||
| T2920 | Berbamine dihydrochloride | 6078-17-7 | 98% |
|
| Berbamine dihydrochloride, a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys. | ||||
| T6128 | PHA-665752 | 477575-56-7 | 98% |
|
| PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs. | ||||
| T1448L | Dasatinib monohydrate | 863127-77-9 | 98% |
|
| Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoti... | ||||
| T7186 | CZC-8004 | 916603-07-1 | 98% |
|
| CZC-8004 is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases. | ||||
| T2116 | AEE788 | 497839-62-0 | 98% |
|
| AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors. | ||||
| T3196 | GNF-7 | 839706-07-9 | 98% |
|
| GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively. | ||||
| T67847 | Imatinib impurities3 | 404844-11-7 | 98% |
|
| Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively. | ||||
| T22553 | Adaphostin | 241127-58-2 | 98% |
|
| This compound is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). | ||||
| T16750 | Rigosertib | 592542-59-1 | 98% |
|
| Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which... | ||||
