Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
説明 | NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. |
ターゲット&IC50 | VEGFR2 (human):9 nM, B-Raf (V599E):76 nM, VEGF2 (mouse):165 nM, c-ABL:99 nM, C-Raf1:24 nM |
細胞研究 | HUVECs or LECs (1.2×103) were seeded into fibronectin-coated 96-well plates. After 24 hours, the cells were transferred into LEC medium containing 2% fetal bovine serum and incubated for an additional 24 hours. Cells(eight wells/condition) were incubated with medium alone(control), 20 ng/ml VEGF-A, or a combination of 20 ng/ml VEGF-A and 1 nmol/L to 1 mol/L NVP-BAW2881. Proliferation was also assayed in LECs incubated with 500 ng/ml VEGF-C. The dimethyl sulfoxide concentration was adjusted to 0.1% in all wells. After 72 hours, cells were incubated with 5-methylumbelliferylheptanoate for subsequent fluorescent quantification of viable cells, using a SpectraMax Gemini electron microscope. (Only for Reference) |
別名 | BAW2881 |
分子量 | 424.38 |
分子式 | C22H15F3N4O2 |
CAS No. | 861875-60-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 78 mg/mL (183.8 mM)
Ethanol: 16 mg/mL (37.7 mM)
You can also refer to dose conversion for different animals. 詳細
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NVP-BAW2881 861875-60-7 Angiogenesis Cytoskeletal Signaling MAPK Tyrosine Kinase/Adaptors VEGFR Raf Bcr-Abl NVP-BAW-2881 NVPBAW2881 inhibit NVP BAW2881 Vascular endothelial growth factor receptor Inhibitor BAW 2881 BAW2881 NVP-BAW 2881 BAW-2881 inhibitor