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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T25913L P-113 acetate 98%
P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and hum...
T26892 Braco-19 351351-75-2 98%
Braco-19 is a telomerase/telomere inhibitor with anti-HIV-1 activity.Braco-19 is a quaternary (GQ)-binding ligand that inhibits tumor growth and inhibits apoptos...
T0028 Gamibetal 924-49-2 98%
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in th...
T11281L FGI-106 tetrahydrochloride 1149348-10-6 98%
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, ...
T35617 Mitoguazone 459-86-9 98%
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
T1815 Dapivirine 244767-67-7 98%
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
TP1809 TAT 191936-91-1 98%
TAT peptide (YGRKKRRQRRR), originating from the human immunodeficiency virus-1 (HIV-1) transactivator of transcription (TAT), enhances the solubility and product...
T76687 Ibalizumab 680188-33-4 98%
Ibalizumab(TMB-355) is a humanized IgG4 monoclonal antibody that acts as a CD4 receptor inhibitor, blocking the entry of HIV-1 into cells by binding to the CD4 r...
T9854 HIV-1 inhibitor-6  1821309-39-0 98%
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibito...
T20000 I-XW-053 5496-35-5 98%
I-XW-053 is a capsid targeted HIV-1 replication inhibitor.
TP1185L Cys-TAT(47-57) acetate(583836-55-9 Free base) 98%
Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.
TN6600 Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside 56317-05-6 98%
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM.
T15371 Gardiquimod 1020412-43-4 98%
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
T69757 PDDC inhibitor 2232878-43-0 98%
PDDC inhibitor (Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate) is a selective and highly potent nSMas...
T24141 HIV-1 Inhibitor 18A 331261-50-8 98%
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) specifically inhibits the entry of multiple HIV-1 isolates.
T9632 CDK9-IN-30 748146-89-6 98%
CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.
T4665 Temsavir 701213-36-7
Temsavir (BMS626529) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
T2239 Raltegravir potassium 871038-72-1
Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
T1776L Plerixafor octahydrochloride 155148-31-5
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
T2830 Betulinic acid 472-15-1
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
P-113 acetate
T25913L
P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and hum...
Braco-19
T26892
Braco-19 is a telomerase/telomere inhibitor with anti-HIV-1 activity.Braco-19 is a quaternary (GQ)-binding ligand that inhibits tumor growth and inhibits apoptos...
Gamibetal
T0028
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in th...
FGI-106 tetrahydrochloride
T11281L
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, ...
Mitoguazone
T35617
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
Dapivirine
T1815
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
TAT
TP1809
TAT peptide (YGRKKRRQRRR), originating from the human immunodeficiency virus-1 (HIV-1) transactivator of transcription (TAT), enhances the solubility and product...
Ibalizumab
T76687
Ibalizumab(TMB-355) is a humanized IgG4 monoclonal antibody that acts as a CD4 receptor inhibitor, blocking the entry of HIV-1 into cells by binding to the CD4 r...
HIV-1 inhibitor-6 
T9854
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibito...
I-XW-053
T20000
I-XW-053 is a capsid targeted HIV-1 replication inhibitor.
Cys-TAT(47-57) acetate(583836-55-9 Free base)
TP1185L
Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside
TN6600
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM.
Gardiquimod
T15371
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
PDDC inhibitor
T69757
PDDC inhibitor (Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate) is a selective and highly potent nSMas...
HIV-1 Inhibitor 18A
T24141
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) specifically inhibits the entry of multiple HIV-1 isolates.
CDK9-IN-30
T9632
CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.
Temsavir
T4665
Temsavir (BMS626529) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
Raltegravir potassium
T2239
Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
Plerixafor octahydrochloride
T1776L
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
Betulinic acid
T2830
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
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