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TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T39669 TLR7/8/9-IN-1 2180127-82-4 98%
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T19675 SM360320 226907-52-4 98%
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addit...
T39654 Afimetoran 2171019-55-7 98%
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
T27034 CL075 256922-53-9 98%
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
TN1936 Mogroside III-E 88901-37-5 98%
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
T8689 Chloroquine 54-05-7 98%
Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the tre...
T24178 Isatoribine 122970-40-5 98%
Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.
T3795 Corilagin 23094-69-1 98%
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T3898 Schaftoside 51938-32-0 98%
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T35593 Semapimod tetrahydrochloride 164301-51-3 98%
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine produ...
T76975 Tomaralimab 1449294-76-1 98%
Tomaralimab
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).
T76089 Pepinh-TRIF TFA 98%
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction )....
T15371 Gardiquimod 1020412-43-4 98%
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
T15017 CU-T12-9 1821387-73-8 98%
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
T23171 Polyinosinic-polycytidylic acid 24939-03-5 98%
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mamm...
T80673 Chloranil 118-75-2 98%
Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflamm...
T60052 BMS-905 2205846-49-5 98%
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
T8503 TLR4-IN-C34 40592-88-9
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T11598 IAXO-102 1115270-63-7
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
T12516 Polyinosinic-polycytidylic acid sodium 42424-50-0
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic...
TLR7/8/9-IN-1
T39669
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
SM360320
T19675
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addit...
Afimetoran
T39654
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
CL075
T27034
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
Mogroside III-E
TN1936
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
Chloroquine
T8689
Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the tre...
Isatoribine
T24178
Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.
Corilagin
T3795
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
Schaftoside
T3898
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
Semapimod tetrahydrochloride
T35593
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine produ...
Tomaralimab
T76975
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).
Pepinh-TRIF TFA
T76089
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction )....
Gardiquimod
T15371
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
CU-T12-9
T15017
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
Polyinosinic-polycytidylic acid
T23171
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mamm...
Chloranil
T80673
Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflamm...
BMS-905
T60052
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
TLR4-IN-C34
T8503
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
IAXO-102
T11598
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
Polyinosinic-polycytidylic acid sodium
T12516
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic...
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