Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T39669 | TLR7/8/9-IN-1 | 2180127-82-4 | 98% |
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TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM. | ||||
T19675 | SM360320 | 226907-52-4 | 98% |
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SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addit... | ||||
T39654 | Afimetoran | 2171019-55-7 | 98% |
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Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases. | ||||
T35593 | Semapimod tetrahydrochloride | 164301-51-3 | 98% |
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Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine produ... | ||||
T76975 | Tomaralimab | 1449294-76-1 | 98% |
Tomaralimab
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Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS). | ||||
T76089 | Pepinh-TRIF TFA | 98% |
|
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Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction ).... | ||||
T15371 | Gardiquimod | 1020412-43-4 | 98% |
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Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m... | ||||
T60052 | BMS-905 | 2205846-49-5 | 98% |
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BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm... | ||||
T8503 | TLR4-IN-C34 | 40592-88-9 |
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TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis | ||||
T3795 | Corilagin | 23094-69-1 |
|
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Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ... | ||||
T23171 | Polyinosinic-polycytidylic acid | 24939-03-5 |
|
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Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mamm... | ||||
T11598 | IAXO-102 | 1115270-63-7 |
|
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IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam... | ||||
T12516 | Polyinosinic-polycytidylic acid sodium | 42424-50-0 |
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Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic... | ||||
TP1938L | RS09 2TFA (1449566-36-2 free base) | TP1938L | 100% |
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RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in... | ||||
T34249 | Rabeximod | 872178-65-9 | 100% |
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Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by ... | ||||
TJS1779 | Protosappanin A | 102036-28-2 | 100% |
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Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf... | ||||
T3898 | Schaftoside | 51938-32-0 | 100% |
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Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity. | ||||
T77353 | MyD88-IN-1 | 2911609-80-6 | 100% |
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MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pat... | ||||
T9645 | CU-115 | 2471982-20-2 | 100% |
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CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β... | ||||
T29099L | VB 201 | 630112-41-3 | 100% |
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VB 201 is an oxidized phospholipid small molecule with anti-inflammatory activity that inhibits CD14 and Toll-like receptor 2-dependent innate cell activation an... |