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VDAC

Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30–40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T3572 NSC 15364 4550-72-5 97.22%
NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.
T18975 DIDS sodium salt 67483-13-0 99.34%
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
T8215 VBIT-12 2089227-65-4 99.45%
VBIT-12 is a potent inhibitor of VDAC1.
T1765 Erastin 571203-78-6 99.6%
Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively ...
T68018 Tuvatexib 2055404-90-3 99.90%
Tuvatexib is a small molecule VDAC/HK2 dual modulator.
T13287 VBIT-4 2086257-77-2 99.93%
VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated ...
NSC 15364
T3572
NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.
DIDS sodium salt
T18975
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
VBIT-12
T8215
VBIT-12 is a potent inhibitor of VDAC1.
Erastin
T1765
Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively ...
Tuvatexib
T68018
Tuvatexib is a small molecule VDAC/HK2 dual modulator.
VBIT-4
T13287
VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated ...