Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
説明 | VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases). |
ターゲット&IC50 | VDAC1:(kd)17 μM |
In vitro | VBIT-4 targets the mitochondrial protein VDAC1, inhibits apoptosis and defends against mitochondrial dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells , IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively).VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention. |
分子量 | 457.87 |
分子式 | C21H23ClF3N3O3 |
CAS No. | 2086257-77-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (98.28 mM), Sonication is recommended.
5% DMSO+95% Saline: 6.25 mg/mL (13.65 mM, suspension)
You can also refer to dose conversion for different animals. 詳細
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VBIT-4 2086257-77-2 Membrane transporter/Ion channel VDAC VBIT4 VBIT 4 Inhibitor inhibitor inhibit