keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 11,000 | |||
100 mg | 在庫あり | ¥ 16,500 | |||
500 mg | 在庫あり | ¥ 57,000 | |||
1 g | 在庫あり | ¥ 90,500 |
説明 | (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
In vitro | Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used |
別名 | VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride |
分子量 | 467.03 |
分子式 | C22H31ClN4O3S |
CAS No. | 1448189-80-7 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(S,R,S)-AHPC hydrochloride 1448189-80-7 Others PROTAC Ligand for E3 Ligase (S,R,S) AHPC hydrochloride VHL Ligand 1 Hydrochloride VH032-NH2 (S,R,S)AHPC hydrochloride inhibit (S,R,S)-AHPC VHL Ligand 1 hydrochloride VHL ligand 1 ULM-1 Ligands for E3 Ligase Protein degrader 1 Hydrochloride VHL ligand-1 ULM1 E3 ligase-recruiting Moiety VHL ligand1 ULM 1 Inhibitor AHPC Hydrochloride Protein degrader 1 hydrochloride inhibitor