store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 110,000 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
100 mg | 在庫あり | ¥ 340,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 105,500 |
説明 | TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1]. |
ターゲット&IC50 | Cereblon:20.4 nM (DC50) |
In vitro | Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells[1]. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%[1]. |
分子量 | 870.07 |
分子式 | C46H59N7O8S |
CAS No. | 2305936-56-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (110.38 mM)
You can also refer to dose conversion for different animals. 詳細
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TD-165 2305936-56-3 Others PROTAC Ligand for E3 Ligase PROTAC-based Inhibitor HEK293T PROTACs TD 165 degrader CRBN inhibit TD165 inhibitor