Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lysosomal membrane and facilitates the release of cysteine proteases into the cytoplasm. Additionally, 1-Dodecylimidazole exhibits hypocholesterolemic and broad-spectrum antifungal activities.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
200 mg | 在庫あり | ¥ 13,000 | |||
500 mg | 在庫あり | ¥ 17,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | 1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lysosomal membrane and facilitates the release of cysteine proteases into the cytoplasm. Additionally, 1-Dodecylimidazole exhibits hypocholesterolemic and broad-spectrum antifungal activities. |
In vitro | N-dodecylimidazole acts as an acid-activated detergent, possessing a pKa of 6.3, and exhibits cytotoxic properties towards cultured cells. Its cytotoxic effects on EMT-6 and MGH U1 cells are dependent on extracellular pH (pHe), demonstrating dose-dependent cell mortality significantly amplified at pHe 6.0, being 100-fold more potent compared to pHe 7.0. |
In vivo | The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase[2].1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats[2]. |
分子量 | 236.4 |
分子式 | C15H28N2 |
CAS No. | 4303-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (423.01 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
1-Dodecylimidazole 4303-67-7 Microbiology/Virology Antifungal conditions Inhibitor Fungal N-Dodecylimidazole acidic extracellular 1 Dodecylimidazole tumors properties inhibit 1Dodecylimidazole detergent inhibitor