keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Magainin II is a member of the antimicrobial peptides family
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 36,000 | |||
5 mg | 在庫あり | ¥ 90,000 | |||
10 mg | 在庫あり | ¥ 134,000 | |||
25 mg | 在庫あり | ¥ 214,500 | |||
50 mg | 在庫あり | ¥ 291,500 | |||
100 mg | 在庫あり | ¥ 388,000 |
説明 | Magainin II is a member of the antimicrobial peptides family |
In vitro | Magainin 2 exhibits bactericidal activity by permeabilizing cell membranes and inducing early apoptosis-like morphological changes in Escherichia coli. It enhances the expression of a bacterial protein with caspase substrate affinity and modulates RecA expression, akin to caspase-like proteins. Notably, it disrupts membranes without significant harm to mammalian cells, targeting primarily the lipid matrix. In Paramecium caudatum, a protozoan, magainin 2 at 10 μg/mL induces osmotic swelling and cell burst by interfering with membrane functions crucial for osmotic regulation. Its mechanism differs in bacterial and mammalian cells; it forms approximately 2.8 nm pores in B. megaterium membranes and crosses into the cytosol, whereas in CHO-K1 cells, it causes significant membrane disturbance, allowing entry of molecules larger than 23 nm, and results in membrane budding and lipid redistribution, notably affecting mitochondria and nuclei. |
分子量 | 2466.9 |
分子式 | C114H180N30O29S |
CAS No. | 108433-95-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mM
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Magainin 2 108433-95-0 Microbiology/Virology Antibacterial Antibiotic Antifungal protozoa cytotoxicity Bacterial AMP phospholipid Inhibitor bacteria antimicrobial peptide Magainin2 gram-negative Magainin-2 cell gram-positive Magainin II inhibit Fungal inhibitor