Powder: -20°C for 3 years | In solvent: -80°C for 1 year
14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
説明 | 14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation. |
In vivo | 14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance and restores Cdyn in Ovalbumin-challenged mice in response to methacholine. |
細胞研究 | A549 cells (3×10^3/well), BEAS-2B cells (5×10^3/well), and RBL-2H3 cells (3×10^3/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120 μM) of 14-deoxy-11,12-didehydroandrographolide for 24 and 48 h at 37°C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. Absorbance is recorded at 490 nm. |
動物実験 | Female BALB/c mice, 6 to 8 weeks old, are sensitized and challenged with OVA. Briefly, mice are sensitized by ip injections of 20 μg of OVA and 4 mg of Al(OH)3 suspended in 0.1 mL of saline on days 0 and 14. On days 22, 23, and 24, mice are challenged with 1% OVA aerosol for 30 min. 14-deoxy-11,12-didehydroandrographolide (0.1, 0.5, and 1 mg/kg) or vehicle (1% DMSO) in 0.1 mL of saline is given by i.p injections 2 h before and 10 h after each OVA aerosol challenge. |
植物由来 |
別名 | AP10, 14-dehydro Andrographolide |
分子量 | 332.43 |
分子式 | C20H28O4 |
CAS No. | 42895-58-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 100 mg/mL (300.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
14-Deoxy-11,12-didehydroandrographolide 42895-58-9 NF-Κb NF-κB AP-10 inhibit Nuclear factor-κB Inhibitor 14 Deoxy 11,12 didehydroandrographolide AP10 14-dehydro Andrographolide Nuclear factor-kappaB 14Deoxy11,12didehydroandrographolide AP 10 inhibitor