Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.
説明 | 5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. |
ターゲット&IC50 | P2X4:0.75 μM |
In vitro | 5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1]. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1]. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1]. |
In vivo | Basal hyperalgesia induced by recurrent NTG injection was completely blocked by 5-BDBD[2]. |
動物実験 | 5-BDBD (28 mg/kg; i.p.; daily for 9 days; male C57BL/6 mice) prevented NTG-induced mechanical hypersensitivity[2]. |
分子量 | 355.19 |
分子式 | C17H11BrN2O2 |
CAS No. | 768404-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (168.92 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
5-BDBD 768404-03-1 Membrane transporter/Ion channel Neuroscience P2X Receptor inhibit P2XRs currents NTG hyperalgesia selective Inhibitor ATP 5BDBD acute 5 BDBD inhibitor