Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 24,500 | |||
5 mg | 在庫あり | ¥ 52,500 | |||
10 mg | 在庫あり | ¥ 85,500 | |||
25 mg | 在庫あり | ¥ 144,500 | |||
50 mg | 在庫あり | ¥ 206,000 | |||
100 mg | 在庫あり | ¥ 280,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 58,000 |
説明 | AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). |
ターゲット&IC50 | Sortilin:330 nM |
In vitro | AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein. |
別名 | AF-38469 |
分子量 | 324.25 |
分子式 | C15H11F3N2O3 |
CAS No. | 1531634-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (123.36 mM)
You can also refer to dose conversion for different animals. 詳細
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AF38469 1531634-31-7 GPCR/G Protein Neurotensin Receptor inhibit Inhibitor AF 38469 AF-38469 inhibitor