Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 27,000 | |||
50 mg | 在庫あり | ¥ 42,000 | |||
100 mg | 在庫あり | ¥ 79,000 | |||
200 mg | 在庫あり | ¥ 114,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
ターゲット&IC50 | Sir2p:60 μM |
In vitro | Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. [1] Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release. [2] |
In vivo | In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation. [3] |
別名 | 1-Naphthalenepropanoic Acid |
分子量 | 198.22 |
分子式 | C13H10O2 |
CAS No. | 5690-03-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.8 mg/mL (100 mM)
Ethanol: 19.8 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Splitomicin 5690-03-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin HDAC 1-Naphthalenepropanoic Acid Inhibitor Histone deacetylases Splitomycin inhibit inhibitor