Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 87,500 |
5 mg | 在庫あり | ¥ 202,500 |
10 mg | 在庫あり | ¥ 280,000 |
25 mg | 在庫あり | ¥ 404,000 |
50 mg | 在庫あり | ¥ 500,500 |
100 mg | 在庫あり | ¥ 643,000 |
説明 | AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation. |
ターゲット&IC50 | GK-GKRP:7 nM, GK:0.02 μM(EC50) |
分子量 | 533.63 |
分子式 | C23H30F3N3O4S2 |
CAS No. | 1361217-07-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (93.7 mM)
You can also refer to dose conversion for different animals. 詳細
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AMG-1694 1361217-07-3 Metabolism Glucokinase AMG 1694 AMG1694 Inhibitor inhibitor inhibit