Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 52,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 157,500 | |||
50 mg | 在庫あり | ¥ 224,000 | |||
100 mg | 在庫あり | ¥ 303,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 57,500 |
説明 | ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays. |
ターゲット&IC50 | ASK1:138 nM(cell), ASK1:21 nM(Biochemical) |
In vitro | ASK1-IN-1 shows good potency with cell IC50 of 138 nM. ASK1-IN-1 has superior CYP inhibition profile[1]. |
In vivo | ASK1-IN-1 shows low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively[1]. |
分子量 | 405.41 |
分子式 | C19H19N9O2 |
CAS No. | 2411382-24-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble)
DMSO: < 1 mg/mL (insoluble or slightly soluble)
DMF: 4 mg/mL (9.87 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ASK1-IN-1 2411382-24-4 Apoptosis ASK CNS inhibit p38 MAPK ASK1 ASK-1-IN-1 ASK1 IN 1 ASK1IN1 MAPK Inhibitor brain penetrant inhibitor