Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in studies to reverse arrhythmias.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 48,500 |
5 mg | 在庫あり | ¥ 122,000 |
10 mg | 在庫あり | ¥ 176,000 |
25 mg | 在庫あり | ¥ 271,000 |
50 mg | 在庫あり | ¥ 365,000 |
100 mg | 在庫あり | ¥ 493,500 |
500 mg | 在庫あり | ¥ 984,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 137,000 |
説明 | AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in studies to reverse arrhythmias. |
ターゲット&IC50 | Inalate:4.3 microM, Inapeak:66 microM |
In vitro | AZD1305 (0.1–30 µM, n = 6, each concentration applied for 3 min ; dog cardiomyocytes) concentration-dependently blocked INalate (IC50=4.3 microM) and INapeak (IC50=66 microM). In PFs, E-4031, but not AZD1305, markedly prolonged APD90 (from 380+/-15 to 597+/-86 ms, P<0.05) after the long CL and augmented APD90 instability (2+/-0.4 to 24+/-6.1 ms, P<0.05), increases significantly attenuated by AZD1305 and lidocaine.[3] |
In vivo | AZD1305 ((36g/kg/min intravenously for 30 minutes ; anesthetized mongrel dogs) respectively increased QT and RR intervals from 290±7 to 397±15 ms (+37%, P<0.0001) and from 603±22 to 778±32 ms (+29%, P=0.002) at normal sinus rhythm. AZD1305 increased the QT interval from 535±28 to 747±36 ms (+40%, P<0.0001). AZD1305 slightly slowed the idioventricular rhythm.[2] |
別名 | UNII-CZO834LXQM, AZD 1305 |
分子量 | 434.5 |
分子式 | C22H31FN4O4 |
CAS No. | 872045-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (57.54 mM)
You can also refer to dose conversion for different animals. 詳細
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AZD-1305 872045-91-5 Others AZD1305 UNII-CZO834LXQM AZD 1305 Inhibitor inhibitor inhibit