Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adarotene (ST1926) is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.
説明 | Adarotene (ST1926) is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells. |
In vitro | Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM [1]. Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium [2]. |
In vivo | Adarotene, administered orally at doses of 30 and 40 mg/kg, significantly extends the lifespan of NB4-bearing SCID mice in a dose-dependent manner without apparent toxicity [2]. At lower doses of 15 and 20 mg/kg, it markedly inhibits tumor growth in human ovarian carcinoma (A2780/DX) and human melanoma (MeWo) models in nude mice [1]. |
別名 | ST1926 |
分子量 | 374.47 |
分子式 | C25H26O3 |
CAS No. | 496868-77-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (120.17 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Adarotene 496868-77-0 Apoptosis Inhibitor ST1926 inhibit ST 1926 ST-1926 inhibitor