Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.
説明 | Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. |
ターゲット&IC50 | CIAP2-BIR3:5.1 nM(Ki), XIAP BIR3:66.4 nM(Ki), CIAP1-BIR3:1.9 nM(Ki) |
別名 | AT-406 HCl, SM-406 |
分子量 | 598.19 |
分子式 | C32H44ClN5O4 |
CAS No. | 1071992-57-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (178.02 mM)
Ethanol: 100 mg/mL (178.02 mM)
H2O: <1 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Xevinapant hydrochloride 1071992-57-8 Apoptosis IAP degradation Xevinapant Hydrochloride mimetic AT-406 ovarian oral AT406 cancer AT-406 HCl Debio-1143 Debio1143 SM 406 Debio 1143 Xevinapant Smac SM406 Inhibitor SM-406 inhibit AT 406 inhibitor