keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 26,000 | |||
2 mg | 在庫あり | ¥ 38,500 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 106,500 | |||
25 mg | 在庫あり | ¥ 172,000 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 317,000 |
説明 | BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM). |
ターゲット&IC50 | α4β7:2 μM, α4β1:4 nM |
In vitro | BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2]. |
In vivo | In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1]. |
分子量 | 708.8 |
分子式 | C36H48N6O9 |
CAS No. | 187735-94-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (352.71 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BIO-1211 187735-94-0 Cytoskeletal Signaling Integrin inhibit BIO1211 BIO 1211 Inhibitor inhibitor