Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 51,000 | |||
25 mg | 在庫あり | ¥ 97,000 | |||
50 mg | 在庫あり | ¥ 146,000 | |||
100 mg | 在庫あり | ¥ 203,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 32,500 |
説明 | Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM). |
In vitro | Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2]. |
In vivo | Boc-D-FMK-fmk significantly reduces apoptosis in hepatocytes of bile duct-ligated rats, potentially enhancing survival rates following endotoxin exposure [3]. A single injection of Boc-D-FMK offers prolonged protection, exceeding 8 weeks, against root avulsion-induced death in motor neurons (MNs), enabling these treated MNs to regenerate axons into an implanted peripheral nerve (PN) graft and successfully reinnervate the target muscle [4]. |
分子量 | 263.26 |
分子式 | C11H18FNO5 |
CAS No. | 634911-80-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (474.82 mM)
You can also refer to dose conversion for different animals. 詳細
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BOC-D-FMK 634911-80-1 Apoptosis Proteases/Proteasome Caspase BOCDFMK Inhibitor inhibit BOC D FMK inhibitor