Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 38,500 | |||
50 mg | 在庫あり | ¥ 57,000 | |||
100 mg | 在庫あり | ¥ 84,000 | |||
500 mg | 在庫あり | ¥ 201,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
In vitro | In hypoxic conditions, Banoxantrone dihydrochloride (AQ4N) undergoes reduction to form AQ4, a stable compound with high DNA affinity. AQ4 acts as a potent inhibitor of topoisomerase II, effectively damaging cells that enter the cell cycle following radiation exposure to the tumor's well-oxygenated regions. Specifically, Banoxantrone dihydrochloride demonstrates significantly higher cytotoxicity (more than 8-fold) in hypoxic environments compared to normoxic ones in 9L rat gliosarcoma and H460 human non-small-cell lung carcinoma cells, without similar effects across 11 other human cancer cell lines. Moreover, the relationship between DT-diaphorase protein levels and Banoxantrone chemosensitivity is weak across these cancer cell lines, and Banoxantrone's effectiveness does not diminish in the presence of DT-diaphorase inhibitors. Banoxantrone dihydrochloride is chemically characterized as a bis-N-oxide, which is sequentially reduced to the tertiary amine AQ4. AQ4 exhibits potent cytotoxicity against both aerobic and hypoxic cells by intercalating into DNA, forming a stable complex that inhibits topoisomerase II, leading to DNA damage and subsequent cell death, a mechanism not observed with AQ4N. |
別名 | AQ4N dihydrochloride, AZD1689 2HCl |
分子量 | 517.4 |
分子式 | C22H30Cl2N4O6 |
CAS No. | 252979-56-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (19.33 mM), Sonication is recommended.
H2O: 10 mg/mL (19.33 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Banoxantrone dihydrochloride 252979-56-9 Immunology/Inflammation NOS Banoxantrone AQ4N dihydrochloride AZD1689 2HCl AQ4N Inhibitor inhibitor inhibit