Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 26,500 |
5 mg | 在庫あり | ¥ 64,500 |
10 mg | 在庫あり | ¥ 95,500 |
25 mg | 在庫あり | ¥ 158,500 |
50 mg | お問い合わせ | ¥ 225,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 66,500 |
説明 | Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
In vitro | The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65. |
植物由来 |
分子量 | 426.72 |
分子式 | C30H50O |
CAS No. | 514-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.27 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Tirucallol 514-46-5 GPCR/G Protein Immunology/Inflammation NO Synthase Prostaglandin Receptor NOS antiinflammatory triterpene Euphorbia tetracyclic inhibit Inhibitor lacteal latex inhibitor