Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
ターゲット&IC50 | MMP1:3 nM , MMP7:6 nM , MMP2:4 nM , MMP9:4 nM , MMP3:20 nM |
In vivo | Matrix density in animals treated with saline or Batimastat (40 mg/kg) is analyzed 4 hours post-E2 administration, a critical point when collagen density notably decreases following hormone treatment [6]. Batimastat intraperitoneally administers to restrict human ovarian carcinoma xenografts and murine melanoma metastasis, alongside delaying primary tumor growth in human breast cancer models without inducing cytotoxicity or affecting mRNA levels [2]. Exhibiting antineoplastic and antiangiogenic effects across tumor models, Batimastat's concomitant application with Cisplatin (60 mg/kg i.p. bi-daily for 8 injections and 4 mg/kg i.v. every 7 days for 3 injections, respectively) effectively halts growth and dissemination of xenografts, maintaining all subjects' health up to day 200 [4]. Furthermore, Kaplan-Meier survival analysis (48 hours) highlights a significant survival rate increase to 95.2% in Batimastat-treated animals versus 75% in controls, with statistical relevance nearing significance (p=0.064) [5]. |
別名 | BB-94 sodium salt |
分子量 | 500.63 |
分子式 | C23H31N3NaO4S2 |
CAS No. | 130464-84-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Batimastat sodium salt 130464-84-5 Proteases/Proteasome MMP Batimastat sodium BB-94 sodium BB-94 sodium salt Inhibitor inhibitor inhibit