Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
説明 | Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity. |
分子量 | 414.47 |
分子式 | C25H23FN4O |
CAS No. | 2290527-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (60.32 mM)
You can also refer to dose conversion for different animals. 詳細
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Bractoppin 2290527-07-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis DNA break phosphopeptide inhibit DNA damage RAD51 G2 arrest Inhibitor BRCA1 tBRCT inhibitor