Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 39,000 | |||
50 mg | 在庫あり | ¥ 63,500 | |||
100 mg | 在庫あり | ¥ 105,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. |
ターゲット&IC50 | RAD51:27.4 μM |
In vitro | RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM).The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231. |
In vivo | B02 substantially improves the therapeutic efficacy of cisplatin against tumor cells in vivo, demonstrating tolerability in mice at dosages up to 50 mg/kg without significant body weight reduction. Mice treated solely with B02 exhibited no tumor growth inhibition; however, those administered 4 mg/kg of cisplatin experienced a 33% reduction in tumor growth. Crucially, a combination treatment involving 50 mg/kg B02 and 4 mg/kg cisplatin resulted in a 66% decrease in tumor size[2]. |
別名 | B02 |
分子量 | 339.39 |
分子式 | C22H17N3O |
CAS No. | 1290541-46-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.9 mg/mL(100 mM)
You can also refer to dose conversion for different animals. 詳細
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RAD51 Inhibitor B02 1290541-46-6 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis B 02 RAD-51 Inhibitor B02 RAD51 Inhibitor B-02 inhibit B02 inhibitor