Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 66,500 | |||
100 mg | 在庫あり | ¥ 106,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase. |
ターゲット&IC50 | BRAG2:3 μM |
In vitro | Administration of 50?μM Bragsin2 inhibits Arf GTPase activation in HeLa cells[1]. Administration of 50?μM Bragsin2 inhibits the growth of breast cancer stem cells including SUM149 and S68, but has no effect on SUM159, which lacks adhesion molecules such as integrin and cadherin[1]. |
別名 | 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one, Bragsin 2 |
分子量 | 289.16 |
分子式 | C11H6F3NO5 |
CAS No. | 342795-08-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (190.21 mM)
You can also refer to dose conversion for different animals. 詳細
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Bragsin2 342795-08-8 Others 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one inhibit Bragsin-2 Inhibitor Bragsin 2 inhibitor