Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,000 | |||
5 mg | 在庫あり | ¥ 86,500 | |||
10 mg | 在庫あり | ¥ 127,000 | |||
25 mg | 在庫あり | ¥ 199,000 | |||
50 mg | 在庫あり | ¥ 273,500 | |||
100 mg | 在庫あり | ¥ 365,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 86,500 |
説明 | CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer. |
ターゲット&IC50 | NF-κB:0.47 μM (EC50), p53:0.37 μM (EC50) |
別名 | Curaxin 137, CBLC137 |
分子量 | 336.43 |
分子式 | C21H24N2O2 |
CAS No. | 1197996-80-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (74.31 mM), Sonication is recommended.
H2O: Insoluble
You can also refer to dose conversion for different animals. 詳細
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CBL0137 1197996-80-7 Apoptosis NF-Κb p53 NF-κB Curaxin 137 CBL 0137 CBLC 137 CBLC-137 CBL-0137 CBLC137 Inhibitor inhibitor inhibit