Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH6953755 is an orally active, potent and selective YES1 kinase inhibitor (IC50:1.8 nM).CH6953755 has anticancer activity and inhibits cancer cell proliferation by inhibiting YES1 kinase.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 114,500 | |||
10 mg | 在庫あり | ¥ 199,500 | |||
25 mg | 在庫あり | ¥ 365,000 | |||
50 mg | 在庫あり | ¥ 581,000 | |||
100 mg | 在庫あり | ¥ 849,500 |
説明 | CH6953755 is an orally active, potent and selective YES1 kinase inhibitor (IC50:1.8 nM).CH6953755 has anticancer activity and inhibits cancer cell proliferation by inhibiting YES1 kinase. |
ターゲット&IC50 | YES1:1.8 nM |
In vitro |
CH6953755 inhibits the growth of cancer cell lines with YES1 amplification in a concentration-dependent manner (0.001-1 μM; 4 days)[1]. Preventing autophosphorylation of YES1 at the Tyr426 site, CH6953755 (0.001-1 μM; 2 hours) upregulates enzymatic activity in KYSE70 cells carrying YES1 amplification[1].In KYSE70 and RERF-LC-AI cells with YES1 amplification, CH6953755 (0.1, 0.3, 1, 3 μM) inhibits TEAD luciferase reporter gene activity[1]. |
In vivo |
CH6953755 exhibits selective antitumor activity in xenograft tumors following oral administration (60 mg/kg/day; 10 days), accompanied by inhibition of phosphorylation at Tyr426 of YES1[1]. In a dose-dependent manner, CH6953755 (oral; 7.5, 15, 30, 60 mg/kg) inhibits phosphorylation at Tyr426 of YES1[1]. |
分子量 | 552.55 |
分子式 | C26H22F2N6O4S |
CAS No. | 2055918-71-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (180.98 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CH6953755 2055918-71-1 Angiogenesis Tyrosine Kinase/Adaptors Src CH-6953755 CH 6953755 Inhibitor inhibitor inhibit