Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 91,500 |
5 mg | 在庫あり | ¥ 223,000 |
10 mg | 在庫あり | ¥ 271,000 |
25 mg | 在庫あり | ¥ 363,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line. |
In vitro |
Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1]. Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2]. At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2]. Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2]. |
別名 | CPS11, CPS 11, N-(Hydroxymethyl)thalidomide |
分子量 | 288.26 |
分子式 | C14H12N2O5 |
CAS No. | 145945-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (156.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CPS-11 145945-21-7 Immunology/Inflammation Metabolism NF-Κb Dehydrogenase NF-κB Reactive Oxygen Species CPS11 CPS 11 N-(Hydroxymethyl)thalidomide Inhibitor inhibitor inhibit