Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
説明 | Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases. |
In vitro | Research on the reproductive toxicity of Isovaleramide in mice, rats, and rabbits demonstrates its potential to be significantly lower than that of VPA. Oral administration of Isovaleramide at a dose of 100 mg/kg resulted in a 90% protection index against maximal electroshock seizures in mice. |
In vivo | At a concentration of 0.15%, Isovaleramide induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. In in vitro assays, 300 μM Isovaleramide inhibits 42% of 3H-FNZ binding to its target site. At concentrations up to 1000 μM, Isovaleramide does not affect the binding and uptake assays of various neurotransmitters in vitro, suggesting that its mechanism of action does not involve direct receptor-mediated effects. |
別名 | 3-Methylbutanamide |
分子量 | 101.15 |
分子式 | C5H11NO |
CAS No. | 541-46-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 16 mg/mL (158.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 16 mg/mL (158.2 mM)
You can also refer to dose conversion for different animals. 詳細
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Isovaleramide 541-46-8 Metabolism Dehydrogenase inhibit Inhibitor 3-Methylbutanamide inhibitor