Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
説明 | CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R. |
ターゲット&IC50 | S1P5:2100 nM(EC50), S1P4:(EC50)56 nM |
In vitro | CYM50308 shows low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1]. |
分子量 | 405.46 |
分子式 | C20H21F2N3O2S |
CAS No. | 1345858-76-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (29.60 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CYM50308 1345858-76-5 GPCR/G Protein S1P Receptor LPL Receptor ML248 Lysophospholipid Receptor selective S1P4-R ML-248 CYM 50308 receptor Inhibitor Potent inhibit CYM-50308 ML 248 inhibitor