keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compound effectively inhibits the secretion of endothelin-1 in a dose-dependent manner.
説明 | Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compound effectively inhibits the secretion of endothelin-1 in a dose-dependent manner. |
In vitro | Atrial natriuretic peptide (ANP), isolated from mammalian hearts, exhibits diuretic, natriuretic, and vasodilatory properties. It has been observed that porcine ANP (1-28) not only inhibits the secretion of immunoreactive endothelin-1 in porcine endothelial cells and aorta upon stimulation with Angiotensin II (Ang II) but also elevates cellular cGMP levels. Similarly, human ANP (1-28) suppresses immunoreactive endothelin-1 secretion and enhances cyclic GMP in human umbilical-vein endothelial cells when stimulated by angiotensin II (ANGII) and thrombin. Moreover, in normal rat glomeruli, Human 125I-ANP (1-28) binds to high-affinity receptors, significantly increasing cGMP without affecting cAMP, showcasing its integral role in electrolyte and fluid homeostasis[1,2,3]. |
別名 | Carperitide acetate (89213-87-6 Free base), Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate |
分子量 | 3140.5 |
分子式 | C129H207N45O41S3 |
CAS No. | 1366000-58-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100mg/ml(31.8mM)
You can also refer to dose conversion for different animals. 詳細
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Carperitide acetate 1366000-58-9 GPCR/G Protein Endothelin Receptor Carperitide Acetate 89213-87-6 Free base 89213-87-6 Carperitide acetate (89213-87-6 Free base) Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Inhibitor inhibitor inhibit