Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
説明 | BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. |
In vitro | BMS-l 82874 inhibited ET-l -stimulated inositol phosphate accumulation (KB 75 nM) and calcium mobilization (Ki = 140 nM) without suppressing the maximal responses in VSM-A10 cells. BMS-182874 competitively inhibited the binding of [125I]ET-1 to ETA receptors in rat vascular smooth muscle A10 (VSM-A10) cell membranes (Ki = 61 nM) and in CHO cells stably expressing the human ETA receptor (Ki = 48 nM), but was a weak inhibitor at ETB receptors (Ki > 50 μM) and non-ET receptors. |
In vivo | BMS-182874 blunted the pressor response to exogenous ET-l when administered either orally (ED50 = 30 μmol/kg) or intravenously (ED50 = 24 μmol/kg) to conscious, normotensive rats. |
分子量 | 381.88 |
分子式 | C17H20ClN3O3S |
CAS No. | 1215703-04-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (130.93 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS 182874 hydrochloride 1215703-04-0 GPCR/G Protein Endothelin Receptor BMS 182874 Hydrochloride BMS-182874 Hydrochloride BMS182874 Hydrochloride Inhibitor inhibitor inhibit