store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 608,500 |
50 mg | 約10-14 週間 | ¥ 792,000 |
100 mg | 約10-14 週間 | ¥ 1,202,500 |
説明 | Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis. |
In vitro | In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
In vivo | Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2]. |
別名 | TOP 3, TOP-3, O-Methylpicrasidine I, TOP3, Kumujian G |
分子量 | 254.28 |
分子式 | C15H14N2O2 |
CAS No. | 65236-62-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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Dehydrocrenatidine 65236-62-6 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK TOP 3 TOP-3 O-Methylpicrasidine I TOP3 Kumujian G Inhibitor inhibitor inhibit