Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects.
説明 | DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects. |
ターゲット&IC50 | COX-2 (human):10 nM, COX-1 (human):800 nM |
In vitro | In HT29 cells, DuP-697 (25-100 nM) causes apoptosis in a concentration-dependent manner. DuP-697 in 1, 10, and 100 nM concentrations cause antiangiogenic effects in HT29 colorectal cancer cells with antiangiogenic scores of 0.5, 0.8, and 1.2[1]. |
In vivo | DuP-697 inhibits bull seminal vesicle prostaglandin synthesis with an IC50 value of 24 μM and rat brain PG synthesis with an IC50 value of 4.5 μM[2]. |
分子量 | 411.31 |
分子式 | C17H12BrFO2S2 |
CAS No. | 88149-94-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.9 mg/mL(90.0 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DuP-697 88149-94-4 Immunology/Inflammation Neuroscience COX DuP697 DuP 697 Inhibitor inhibitor inhibit