Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 36,500 | |||
50 mg | 在庫あり | ¥ 53,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,000 |
説明 | Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. |
ターゲット&IC50 | Topo I:0.31 μM |
In vitro | Dxd shows obviously suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines with IC50s of 26.8, 25.4, and 6.7 ng/mL respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL)[1]. |
In vivo | Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM. In HER2 low-expressing ST565 and ST313 models has HER2 IHC 1+/FISH-negative expression[1]. |
別名 | Exatecan derivative for ADC, OQM5SD32BQ, UNII-OQM5SD32BQ |
分子量 | 493.48 |
分子式 | C26H24FN3O6 |
CAS No. | 1599440-33-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: insoluble
DMSO: 50 mg/mL (101.32 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Dxd 1599440-33-1 DNA Damage/DNA Repair Topoisomerase Inhibitor ADC Exatecan derivative for ADC ADC Cytotoxin inhibit OQM5SD32BQ UNII-OQM5SD32BQ HER2-targeting ADC Payload inhibitor