Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
説明 | EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). |
分子量 | 368.34 |
分子式 | C19H14F2N4O2 |
CAS No. | 1808714-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.63 mg/mL (12.57 mM), Sonication is recommended.
Ethanol: 1.10 mg/mL (2.99 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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EN6 1808714-73-9 Autophagy Membrane transporter/Ion channel Proton pump inhibit Inhibitor Proton Pump EN-6 EN 6 inhibitor