Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約8-10 週間 | ¥ 85,500 |
25 mg | 約8-10 週間 | ¥ 275,500 |
50 mg | 約8-10 週間 | ¥ 360,500 |
100 mg | 約8-10 週間 | ¥ 542,000 |
1 mL * 10 mM (in DMSO) | 約8-10 週間 | ¥ 105,000 |
ターゲット&IC50 | 5-HT1A receptor:24 nM (EC50) |
In vivo | Flesinoxan functions as a partial agonist at postsynaptic and a full agonist at presynaptic 5-HT1A receptors. Its intravenous delivery inhibits the activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons, bearing a similar antagonistic effect on 5-HT's influence on CA3 pyramidal neurons as 8-OH-DPAT. Studies of acute brain penetration revealed that nine minutes post-intravenous administration, [3H]8-OH-DPAT achieves significantly higher brain concentrations than [3H]Flesinoxan. Both Flesinoxan and 8-OH-DPAT, when administered subcutaneously, induce dose-dependent hypothermia, with Flesinoxan's effect being notably reduced by the pre-administration of pindolol, a non-selective 5-HT1A antagonist, and methysergide, a 5-HT1/2 antagonist. Comparable levels of hypothermia are observed with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT, though Flesinoxan's peak effect transpires 30 minutes later than that of 8-OH-DPAT and diminishes more gradually. |
分子量 | 415.46 |
分子式 | C22H26FN3O4 |
CAS No. | 98206-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (75.22 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Flesinoxan 98206-10-1 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit