Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
説明 | Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
In vitro | Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4] |
In vivo | In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2] |
別名 | NSC9168, Amebacilin |
分子量 | 458.54 |
分子式 | C26H34O7 |
CAS No. | 23110-15-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.04 mM)
You can also refer to dose conversion for different animals. 詳細
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Fumagillin 23110-15-8 Microbiology/Virology Others Proteases/Proteasome HIV Protease Parasite Antibiotic inhibit NSC9168 Amebacilin NSC 9168 Human immunodeficiency virus Inhibitor HIV NSC-9168 inhibitor